Eliminating Senescent Cells may be the Key to Longer, Healthier Lives, Says Alan Cash of MetVital

 As scientists better understand the process of aging, they are making great strides in reversing some of its symptoms. In a recent study published in the journal Cell Death and Disease, researchers from the University of Alabama at Birmingham were able to accelerate and reverse skin aging and wrinkling in mice. The study showed that the key to skin aging and hair loss appears to be mitochondrial malfunction. 

 Would you like smoother, younger-looking skin? Consider supplementing your diet with oxaloacetate! Here, MetVital CEO Alan Cash discusses how benaGene (oxaloacetate) may protect your cells and slow the aging process in your skin by protecting your mitochondria. 

"Wrinkled skin and hair loss are obvious features of skin aging and aging-associated phenotypic changes in humans. We discovered that these aging-associated phenotypic changes could be reversed by restoring mitochondrial DNA content to wild-type level. To our knowledge this observation is unprecedented." (1) 


The scientists developed a special mouse wherein they could disable mitochondrial DNA genes, or turn them back on.
 
".... These mice showed reduced mtDNA content, reduced mitochondrial gene expression, and instability of supercomplexes involved in oxidative phosphorylation (OXPHOS) resulting in reduced OXPHOS enzymatic activities. We demonstrate that ubiquitous depletion of mtDNA in mice leads to predominant and profound effects on the skin resulting in wrinkles and visual hair loss with an increased number of dysfunctional hair follicles and inflammatory responses.... mtDNA-repleter mice showed that by turning off the mutant POLG1 transgene expression, mitochondrial function, as well as the skin and hair pathology, is reversed to wild-type level. " (1)

Mitochondria, the power-plants of your cells, function through a process called oxidative phosphorylation (OXPHOS) in which oxygen is used to burn fuel and make chemical energy (adenosine triphosphate, ATP) for cells. The mitochondria have 13 unique genes for OXPHOS, and an additional 85 genes for OXPHOS reside in the nucleus of the cell. Keeping mitochondrial DNA safe and supporting OXPHOS is key to mitochondrial health. However, with normal aging, working mitochondria decrease in function and density in the cells. Outside of normal aging, mitochondrial depletion is a scary thing; this phenomenon is implicated in serious human diseases including cardiovascular disease, diabetes, age-associated neurological disorders, and cancer. 

"A recent study revealed that humans on average lose about four copies of mtDNA every ten years. This study also identified an association of decrease in mtDNA copy number with age-related physiological parameters." (1) 
 
Alan Cash explains that part of the reason that mitochondrial loss causes skin and hair aging is because it also increases inflammation. NF-kB, a master regulator of the inflammatory response, is increased in mice with mitochondrial dysfunction. 

benaGene (oxaloacetate) supplementation fights aging through multiple mechanisms. It has been proven to protect mitochondrial DNA from damage in animal tests. (2) We know of no other compound that has been shown to protect mitochondrial DNA from damage. Additionally, benaGene (oxaloacetate) has been shown to increase OXPHOS, (3, 4) and increase the rate of the Krebs Cycle. (5) Lastly, benaGene (oxaloacetate) has been shown to reduce the NF-kB inflammation pathway by up to 50% in animal models. (3) 

We are aware of the benefits of benaGene (oxaloacetate) with regard to various age-related symptoms through added mitochondrial support; however, the reduction of skin and hair aging may be a new benefit of this supplement. 

Many people say that "beauty comes from within.” Perhaps a more accurate statement is that "beauty comes from within the cell,” and benaGene can help. 

About Alan Cash

Alan Cash, MetVital CEO and founder, has gained recognition and awards from the White House, INC 500 business, Ernst & Young Entrepreneur of the Year, Deloitte and Touche Technology Fast 50 and Top 100 Hotfirm. He has invented and brokered technology to major firms including Mitsubishi Heavy Industry (MHI), Vivendi, and has substantial experience dealing with US Federal regulatory agencies that have provided oversight for his work at the Department of Energy, the Department of Defense, and the Environmental Protection Agency. Mr. Cash provided the initial research into oxaloacetate and it’s stabilization, using the compound as a calorie restriction mimetic. He has partnered with both academia and government to move this research forward, working with UCSD, UCLA, University of Kansas, Pennington Biomedical Laboratory, and the National Institute on Aging (part of the NIH). This same science is being examined for a variety of human diseases. Mr. Cash also has an MS in physics from the University of Oklahoma.

References and Additional Reading

1. Singh B, Schoeb TR, Bajpai P, Slominski A, Singh KK. Reversing wrinkled skin and hair loss in mice by restoring mitochondrial function. Cell Death Dis. 2018;9(7):735. 

2. Yamamoto HA, Mohanan PV. Effect of alpha-ketoglutarate and oxaloacetate on brain mitochondrial DNA damage and seizures induced by kainic acid in mice. Toxicol Lett. 2003;143(2):115-22. 

3. Wilkins HM, Harris JL, Carl SM, E L, Lu J, Eva Selfridge J, et al. Oxaloacetate activates brain mitochondrial biogenesis, enhances the insulin pathway, reduces inflammation and stimulates neurogenesis. Hum Mol Genet. 2014;23(24):6528-41. 

4. Wilkins HM, Koppel S, Carl SM, Ramanujan S, Weidling I, Michaelis ML, et al. Oxaloacetate Enhances Neuronal Cell Bioenergetic Fluxes and Infrastructure. J Neurochem. 2016. 

5. Haas RH, Thompson G, Morris B, Conright K, Andrews T. Pyruvate dehydrogenase activity in osmotically shocked rat brain mitochondria: stimulation by oxaloacetate. J Neurochem. 1988;50(3):673-80. 
 
 
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